News & Publications

Press Releases:

Selected Publications in (Peer-Reviewed) Scientific Journals:

1. Sackellares JC, Shiau DS, Halford JJ, LaRoche SM, Kelly KM. Quantitative EEG analysis for automated detection of nonconvulsive seizures in intensive care units. Epilepsy Behavior, 22(S1): 69-73, 2011.
2. Kelly KM, Shiau DS, Jukkola PI, Miller ER, Mercandante A, Quigley MM, Nair SP and Sackellares, JC. Effects of age and cortical infarction on EEG dynamic changes associated with spike and wave discharges in F3444 rats. Experimental Neurology, 232(1): 15-21, 2011.
3. Kelly KM, Shiau DS, Kern RT, Chien JH, Yandora K, Valeriano J, Halford J, Sackellares JC. Assessment of a Scalp EEG-based automated seizure detection system. Clinical Neurophysiology, 121: 1832-1843, 2010.
4. Shiau DS, Halford J, Kelly KM, Kern RT, Inman M., Chien JH, Pardalos PM, Yang MCK, Sackellares JC. Signal Regularity-Based Automated Seizure Detection System for Scalp EEG Monitoring. Cybernetics and Systems Analysis, in press (October, 2010).
5. Halford JJ, Shiau DS, Kern RT, Stroman C, Kelly KM, Sackellares, JC. Seizure Detection Software Used to Complement the Visual Screening Process for Long-Term EEG Monitoring. American Journal of Electroneurodiagnostic Technology (AJET), 50(2): 133-147, 2010.
6. Mammone N, Principe JC, Morabito FC, Shiau DS, and Sackellares JC. Visualization and modeling of STLmax topographis brain activity maps. Journal of Neuroscience Methods, 189: 281-294, 2010.
7. Nair SP, Shiau DS, Principe JC, Iasemidis LD, Pardalos PM, Norman WM, Carney PR, Kelly KM, and Sackellares JC. An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent. Experimental Neurology, 216(1): 115-121, 2008.
8. Nair SP, Jukkola PI, Quigley M, Wilberger A, Shiau DS, Sackellares JC, Pardalos PM, and Kelly KM. Absence seizures as resetting mechanisms of brain dynamics. Cybernetics and Systems Analysis, 44 (5): 664-672, 2008.
9. Liu CC, Pardalos PM, Chaovalitwongse WA, Shiau DS, Ghacibeh G, Suharitdamrong W, and Sackellares JC. Quantitative complexity analysis in multi-channel intracranial EEG recordings from epilepsy brains. Journal of Combinatorial Optimization 15(3): 276-286, 2008.
10. Sackellares JC, Shiau DS, Principe JC, Yang MCK, Dance LK, Suharitdamrong W, Chaovalitwongse W, Pardalos PM and Iasemidis LD. Predictability Analysis for an Automated Seizure Prediction Algorithm. Journal of Clinical Neurophysiology, 29 (6): 509-520, 2006.
11. Chaovalitwongse W, Pardalos PM, Iasemidis LD, Carney PR, Shiau D-S, Suharitdamrong W, and Sackellares JC. A robust method for studying the dynamics of the intracranial EEG: Application to epilepsy. Epilepsy Research, 64: 93-113, 2005.
12. Iasemidis LD, Shiau DS, Pardalos PM, Chaovalitwongse W, Narayanan K, Prasad A, Tsakalis K, Carney PR, and Sackellares JC. Long-Term Prospective On-Line Real-Time Seizure Prediction. Clinical Neurophysiology, 116 (3): 532-544, 2005.
13. Pardalos PM, Chaovalitwongse W, Iasemidis LD, Sackellares JC, Shiau DS, Carney PR, Prokopyev OA, and Yatsenko VA. Seizure warning algorithm based on optimization and nonlinear dynamics. Mathematical Programming, Ser. B, 101 (2): 365-385, 2004. Paper award: The 2004 William Pierskalla best paper award for research excellence in health care management science, Institute for Operations Research and the Management Sciences (INFORMS), 2004.
14. Iasemidis LD, Shiau DS, Sackellares JC, Pardalos PM, and Prasad A. Dynamical resetting of the human brain at epileptic seizures: application of nonlinear dynamics and global optimization techniques. IEEE Transactions on Biomedical Engineering, 51 (3): 493-506, 2004.
15. Iasemidis LD, Shiau DS, Chaowolitwongse W, Prasad A, Veeramani B, Sackellares JC, Pardalos PM, Carney PR, and Tsakalis K. Adaptive Epileptic Seizure Prediction System. IEEE Transactions in Biomedical Engineering, 15 (5): 616-627, 2003.

Recent Conferences:

  • 2013 AES Meeting
    • December 7-9, 2013 in Washington, DC
    • The Optima Research Team presented an abstract titled:
    • “Automated detection of electrographic seizures in pediatric EMU patients through analysis of scalp EEG”
  • 2013 NISS
    • May 12 - 16, 2013 in Washington, DC
    • Recipient of the TechConnect National Innovation Award
    • Ryan T. Kern, MD presented “CereScope™ - A Portable All-in-One Neurological Monitoring System”
  • 2013 ACNS Meeting
    • February 5 - 10, 2013 in Miami, FL
    • J. Chris Sackellares, MD and Deng-Shan Shiau, PhD led the Annual Courses Program titled “Seizure Detection”
    • J. Chris Sackellares, MD and Deng-Shan Shiau, PhD led the discussion on “What’s This Pattern? Seizures, Periodic Discharges, or Ictal-Interictal Continuum
  • 2012 AES Meeting
    • November 30 - December 4, 2012 in San Diego, CA
    • The Optima Research Team presented an abstract titled:
    • “Automated detection of periodic discharges in ICU patients through analysis of scalp EEG”
  • 2011 AES Meeting
    • December 2-6, 2011 in Baltimore, MD
    • The Optima Research Team presented an abstract titled:
    • “Automated detection of nonconvulsive seizures in ICU through analysis of scalp EEG”
  • 2010 AES Meeting
    • December 3-7, 2010 in San Antonio, TX
    • The Optima Research Team presented an abstract titled:
    • “Quantitative EEG Trending for Monitoring Non-Convulsive Seizures in ICU Patients”
  • 2009 AES Meeting
    • December 4-8, 2009 in Boston, MA
    • The Optima Research Team presented two abstracts titled:
    • “Validation Study of an Automated Seizure Detection Algorithm in Scalp EEG” “Epileptic Seizure Prediction by Scalp EEG Analysis”
    • Launched IdentEvent® at Optima Neuroscience Exhibit
  • 4th International Workshop on Seizure Prediction
    • June 4-7, 2009 in Kansas City, Missouri
    • J. Chris Sackellares, MD presented "Seizure Prediction and Detection Research at Optima Neuroscience"
    • Deng-Shan Shiau, PhD presented a poster titled “Epileptic Seizure Prediction by Scalp EEG Analysis”
  • 2008 AES Annual Meeting
    • December 5-9, 2008 in Seattle, Washington
    • The Optima Research Team presented two abstracts titled:
    • “Automated Detection of Epileptic Seizures Based on Spatiotemporal Dynamics of Scalp EEG Signals” “Ictal Dynamics in scalp EEG”

  • CIMIT/NIO Epilepsy Innovation Summit
    • May 7, 2008 in Boston, Massachusetts
    • J. Chris Sackellares, MD presented lecture titled “Seizure Prediction and Monitoring”
 
       
 
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